Products are independently selected by our editors.

We may earn an affiliate commission from links.

PDRN, or polydeoxyribonucleotide, is the active ingredient in salmon-sperm facials.

Image may contain Face Head Person Photography Portrait Happy Smile Baby and Freckle

Sam Spence

Its a fragment of DNA, saysDr.

Eunice Park, dual-board-certified facial plastic and reconstructive surgeon and the founder ofAIREMin New York.

(Not outright sperm, as hype would lead you to believe.)

Image may contain: Bottle, Lotion, and Shaker

Vogues Favorite PDRN Skin-Care Products

The most common pro-grade treatment youll see is Rejuran Healing Essence.

Rather than injecting it, Park applies it to the skin aftermicroneedlingor lasering.

Its like a vitamin boost to the skin, she says.

Image may contain: Bottle, and Cosmetics

These should all include a version of DNA fragments, says Fu.

However, the labels dont tell you where the DNA fragments would be sourced from.

How long does it take to see the results from PDRN?

Image may contain: Face, Head, Person, Cosmetics, Face Makeup, Makeup, Tape, and Bottle

Do topical PDRN products work as well as in-office treatments?

Deeper penetration of an active translates to more dramatic improvement in a faster amount of time.

However, the more affordable and convenient nature of at-home PDRN serums make them worthy of consideration.

Image may contain: Bottle, and Shaker

Meet the Experts

Image may contain: Bottle, Lotion, Cosmetics, Food, and Ketchup

Image may contain: Bottle, Cosmetics, and Deodorant

Image may contain: Bottle, Lotion, and Cosmetics

Image may contain: Bottle, Cosmetics, and Perfume

Image may contain: Bottle, Cosmetics, Perfume, and Aftershave